Read e-book online Angiotensin II Receptor Blockade: (Progress in Experimental PDF

By Naranjan S. Dhalla,Peter Zahradka,Ian M.C. Dixon,Robert E. Beamish

the connection among angiotensin II and high blood pressure used to be demonstrated in 1898 while angiotensin II used to be proven to modulate systemic blood strain. Over the intervening a long time, an entire characterization of the renin-angiotensin approach (RAS) has been completed, and our figuring out of its biochemistry and body structure has resulted in the directed improvement of brokers such ·as ACE inhibitors and receptor antagonists in a position to controlling high blood pressure. extra lately, it was once proven that angiotensin II is secreted inside of convinced tissues and that those tissue-specific structures function independently of the systemic RAS. the radical idea that angiotensin II regulates a couple of cardiovascular techniques which are unrelated to blood strain has renewed the curiosity of either easy and scientific scientists in angiotensin II. The organization among angiotensin II and cardiac development, specifically, has indicated that remedies at present in use for high blood pressure can have direct program to the therapy of center failure. The Manitoba Cardiovascular discussion board on Angiotensin Receptor Blockade in Winnipeg was once convened October 18-20, 1996 to envision the medical and easy features of angiotensin receptor biology as they observe to high blood pressure and middle failure. additionally, the aptitude therapy of those stipulations utilizing particular angio­ tensin receptor antagonists was once addressed in the context in their speedy healing software and destiny potential.

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Angiotensin II Receptor Blockade: (Progress in Experimental Cardiology) by Naranjan S. Dhalla,Peter Zahradka,Ian M.C. Dixon,Robert E. Beamish

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